The role of AKT/PI3K Signaling in the Development of Alzheimer Disorder

The role of AKT/PI3K Signaling in the Development of Alzheimer Disorder

The role of AKT/PI3K Signaling in the Development of Alzheimer Disorder

Part 1: introduction
The introduction should be a very short synthetic paragraph written in your own words,. It will present the common aim and the key conclusions of the two research papers that were presented in Journal Club and will explain which point that they failed to answer motivated to your literature search. This should be written in the style of the introduction of a research paper, with citations indicating where the information comes from. Suggested length: between 5 and 10 lines of typed text.
1- Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology.
2-The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid.
Part 2: reading note on 3 key resreach articles
This will be an annotated list of the 3 original research articles (not reviews) that you will have found in literature databases and that you think provide the most important information cited in your mini-essay. Do not include the reading notes of the two lead articles used in Journal Club, which have already been assessed.
Format: Each reading note must have a title, which is the title of the article, followed by a citation in Harvard format. The reading notes should summarise in your own words the findings reported in the articles, any relevant extra details that could not be included in the discussion and conlcusion (e.g. methodologies or an important specific experiment) and a short explanation as to why you selected this as being important to your essay. The reading note must not contain material copied or mechanically paraphrased from the articles. Suggested length: between 10 and 16 lines per note.
theses are the peer-reviews:
1-PI3 kinase signaling is involved in Aß-induced memory loss in Drosophila.
2- The PI3K-Akt-mTOR pathway regulates Aß oligomer induced neuronal cell cycle events
3- Amyloid-b Interrupts the PI3K-Akt- mTOR Signaling Pathway That Could Be Involved in Brain-Derived Neurotrophic Factor-Induced Arc Expression in Rat Cortical Neurons
Part 2: Discussion and conclusion
This will be an annotated list of the 3 original research articles (not reviews) that you will have found in literature databases and that you think provide the most important information cited in your mini-essay. Do not include the reading notes of the two lead articles used in Journal Club, which have already been assessed.
Format: Each reading note must have a title, which is the title of the article, followed by a citation in Harvard format. The reading notes should summarise in your own words the findings reported in the articles, any relevant extra details that could not be included in the discussion and conlcusion (e.g. methodologies or an important specific experiment) and a short explanation as to why you selected this as being important to your essay. The reading note must not contain material copied or mechanically paraphrased from the articles. Suggested length: between 10 and 16 lines per note.
include a small paragraph include the limitation of the studies.
Part 4 – References
This will be the list of all articles cited in your mini-essay, including the two journal club articles, the three additional key articles identified by you and any additional relevant references (including one review article should you need to use one for background information).
Each reference must be given in full (with article titles) and in the Harvard format as described in tutorial and in the “quote-Unquote” guide.

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