As with any medication there is risk for side effects. In this case the term is treatment-resistant depression and refers to effects such as weight gain, memory lapse, and even suicidal ideation (Advokat et. Al., 2014). This tends to happen more in those with less severe symptoms.
Anti-depressants are hugely beneficial in more severe cases and in comorbid treatment plans though. Specified therapies can also have a great and positive effect on sufferers as pointed out by McLean (2018) and Mennin et. Al. (2018). With no treatment at all symptoms are sure to escalate, not diminish, over time. Sometimes even with treatment, but typically without, suicide becomes the biggest risk.
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